子宫体原发性弥漫性大B细胞淋巴瘤临床病理观察

目的探讨子宫体原发性弥漫性B细胞淋巴瘤的病理诊断与鉴别诊断要点。方法对2例子宫体原发性弥漫性B细胞淋巴瘤进行临床病理特点观察,使用LCA、CD30、CD79a、CD68、CD45RO、CD3、CD20和CEA等免疫组化染色辅助诊断,并文献复习。结果子宫体原发性弥漫性B细胞淋巴瘤临床诊断困难,镜下病理形态多样,可见子宫内膜和/或肌层内淋巴样细胞增生,免疫组化B细胞标记（＋）。结论子宫原发性弥漫性B细胞淋巴瘤少见,临床易漏诊且侵袭性较高,因此准确、完整的病理诊断对预后治疗十分重要,免疫组化有辅助诊断作用。

Pathologic diagnosis of primary diffuse large B-cell lymphoma in uterine body: Two cases report

Objective To study the pathologic diagnosis and differential diagnosis of primary diffuse large B-cell lymphoma of uterine body. Methods 2 cases of primary diffuse large B-cell lymphoma of uterine body were reported. Immunohistochemical stains for LCA, CD30, CD79a, CD68, CD45RO, CD3, CD20 and CEA were performed and also related literatures reviewed. Results The clinical diagnosis of primary diffuse large B-cell lymphoma of uterine body was difficult. The pathological feature was various. There was proliferation of lymphoid cells in endometrium and muscular layers of womb. Large B cells were identified with immanohistochemical staining. Conclusion The primary diffuse large B-cell lymphoma of uterine body is rare with high invasive capacity and easily mis-diagnosed. Accurate and complete diagnosis is very important for this tumor because the treatment and prognosis are different for different histological types. Immunohistochemistry is useful for pathologic diagnosis of this tumor.