Use of immunohistochemical markers can refine prognosis in triple negative breast cancer |
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| Authors: | Marc Tischkowitz Jean-Sébastien Brunet Louis R Bégin David G Huntsman Maggie CU Cheang Lars A Akslen Torsten O Nielsen William D Foulkes |
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| Affiliation: | 1.Program in Cancer Genetics,McGill University,Montréal,Canada;2.Cancer Prevention Centre,Segal Cancer Centre, Sir M.B. Davis-Jewish General Hospital,Montréal,Canada;3.Algorithme Pharma,Laval,Canada;4.H?pital du Sacré-Coeur de Montréal,Québec,Canada;5.Genetic Pathology Evaluation Centre,BC Cancer Agency, UBC,Vancouver,Canada;6.The Gade Institute, Section for Pathology,University of Bergen and Haukeland University Hospital,Bergen,Norway |
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| Abstract: | Background Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of immunohistochemical (IHC) staining patterns, particularly in retrospective studies where material for expression profiling may not be available. The IHC pattern that best defines basal-like tumors is under investigation and various combinations of ER, PR, HER2-, CK5/6+ and EGFR+ have been tested. |
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