FDG PET/CT in carcinoma of unknown primary |
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| Authors: | Thomas C. Kwee Sandip Basu Gang Cheng Abass Alavi |
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| Affiliation: | (1) Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands;(2) Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA;(3) Radiation Medicine Center (Bhabha Atomic Research Center), Tata Memorial Center Annexe, Bombay, India |
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| Abstract: | Carcinoma of unknown primary (CUP) is a heterogeneous group of metastatic malignancies in which a primary tumor could not be detected despite thorough diagnostic evaluation. Because of its high sensitivity for the detection of lesions, combined 18F-fluoro-2-deoxyglucose positron emission tomography (FDG PET)/computed tomography (CT) may be an excellent alternative to CT alone and conventional magnetic resonance imaging in detecting the unknown primary tumor. This article will review the use, diagnostic performance, and utility of FDG PET/CT in CUP and will discuss challenges and future considerations in the diagnostic management of CUP. |
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