On the Mechanism of Antifibrillatory Effect of Afobazole |
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Authors: | S A Kryzhanovskyi V N Stolyaruck M B Vititnova I B Tsorin S B Seredenin |
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Institution: | V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. sak538@yandex.ru |
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Abstract: | Effect of afobazole on the threshold of electrical fibrillation of the heart was studied on anesthetized rats with intact
myocardium. It was shown that the drug considerably increased the threshold of electrical fi brillation of the heart, being
not inferior to reference class I antiarrhythmic drugs (lidocaine and procainamide) according to V. Williamse classification.
Against the background of preliminary injection of σ-receptor antagonist haloperidol, afobazole exhibited no antifibrillatory
activity. These findings and analysis of published reports suggest that antifibrillatory activity of afobazole is determined
by its antagonistic influence on σ1-receptors localized in cardiomyocyte cytosol. |
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