| 不同碘摄入量对子代小鼠海马神经元影响的研究 |
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| 引用本文： | 杜娥,任建丽,宋翠荣,刘皓,陈祖培.不同碘摄入量对子代小鼠海马神经元影响的研究[J].中国地方病防治杂志,2009(5):336-338. |
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| 作者姓名： | 杜娥 任建丽 宋翠荣 刘皓 陈祖培 |
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| 作者单位： | 天津市泌尿外科研究所;德州市人民医院;沧州市高等专科学校;天津医科大学组胚教研室; |
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| 摘 要： | 目的探讨碘缺乏和碘过量对子代小鼠海马CA3区神经元的影响。方法断乳后1个月Balb/c小鼠,雌雄各半,随机分为5组：低碘组（LI）,适碘组（NI）,5倍碘组（5HI）,10倍碘组（10HI）,50倍碘组（50HI）,给予不同浓度的碘化钾碘水,饲养3个月后雌雄合笼,取40日龄子代小鼠脑组织,应用免疫组织化学技术观察海马CA3区神经元,并进行形态计量学分析。结果与NI组相比,5HI组、10HI组NSE阳性神经元面数密度及平均光密度无明显变化,差异无统计学意义; LI组、50HI组面数密度及平均光密度有不同程度的下降,且有统计学意义。结论脑发育临界期碘缺乏及严重碘过量会影响子代小鼠海马神经元的发育,且碘缺乏的影响较碘过量严重。
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| 关 键 词： | 碘缺乏 碘过量 海马 NSE 神经元 |
Study on the relationship between different iodine intakes and the development of hippocampal neuron in filial generation of mice |
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| DU E,REN Jian-li,SONG Cui-rong,et al.Study on the relationship between different iodine intakes and the development of hippocampal neuron in filial generation of mice[J].Chinese Journal of Control of Endemic Disenaces,2009(5):336-338. |
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| Authors: | DU E REN Jian-li SONG Cui-rong |
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| Institution: | DU E,REN Jian-li,SONG Cui-rong,et al(Tianjin Institute of Urology,Tianjin 300211,China) |
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| Abstract: | Objective To study the relationship between different iodine intakes and the development of cerebral hippocampal NSE neuron in filial generation of Balb/c mice.Methods The mice were divided into five groups(LI,NI,5HI,10HI,50HI) by drinking water with different iodine concentrations.After three months,the mice mated and their first filial generations of 40-day were observed.The expression of NSE were examined by immunohistochemistry,the numerical density on area and the average of optical density were measur... |
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| Keywords: | Iodine deficiency Iodine excess Hippocampus Neuron |
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