Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF |
| |
| Authors: | James P. Bertram Millicent F. Rauch Kaliq Chang Erin B. Lavik |
| |
| Affiliation: | (1) Department of Biomedical Engineering, Yale University, 55 Prospect Street, Malone Engineering Center, New Haven, Connecticut 06520, USA;(2) Department of Anesthesiology, Columbia University Medical Center, New York, New York 10032, USA;(3) Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA; |
| |
| Abstract: | Purpose Brain-derived neurotrophic factor (BDNF) plays an important role in neuroprotection and repair, but long-term delivery from polymer systems has been challenging. We investigated the role the chemistry of the polymer played in loading and delivery of BDNF via microspheres, which are suitable for minimally invasive administration. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
