皮肤病理性瘢痕的基础理论研究与进展*★

皮肤病理性瘢痕是整形外科的常见疾病，包括增生性瘢痕和瘢痕疙瘩，病理性瘢痕发病机制参与的因素众多，目前并未完全清楚。研究认为病理性瘢痕的形成主要是由于成纤维细胞的过度生长和胶原蛋白合成、分泌紊乱以及过度沉积所造成。本文对病理性瘢痕发生的背景、瘢痕成纤维细胞的培养及检测、胶原蛋白的检测及瘢痕动物模型的研究等进行了分析和总结，通过对瘢痕的基础研究，希望能为下一步基础研究和临床治疗提供证据和启发。

Basic research progress in pathological scar of skin

Pathological scar of skin is a common disease in orthopaedic surgery. It includes hypertrophic scar and keloid. Pathogenesy of the pathological scar is not clear, there are many factors affecting the pathogenesy of the skin scar. Present researches show that formation of pathological scar was mainly due to the excessive fibroblast growth, disorder of collagen protein synthesis and secretion and excessive deposition. In this article, we analyzed and summarized the pathological scars in the background, training and detecting the scar fibroblasts, detecting the collagen protein and animal model of scar research. By discussing the basic research of scar, we can give evidence and inspiration to the basic research and clinical treatment of pathological scars in the future.