| 黄芩苷滴丸的制备工艺优选 |
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| 引用本文： | 毛柳珺,陈薇,廖曾珍,赵志英.黄芩苷滴丸的制备工艺优选[J].海峡药学,2014,0(7):24-26. |
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| 作者姓名： | 毛柳珺 陈薇 廖曾珍 赵志英 |
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| 作者单位： | 毛柳珺 (广西桂林医学院附属医院 桂林 541001)； 陈薇 (广西桂林医学院附属医院 桂林 541001)； 廖曾珍 (广西桂林医学院附属医院 桂林 541001)； 赵志英 (中国药科大学 南京211198)； |
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| 基金项目： | 国家自然科学基金(项目编号：81202929) |
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| 摘 要： | 目的优化黄芩苷滴丸制备工艺，考察药物体外释放度。方法以聚乙二醇6000（PEG6000）．共聚雏酮（PVPS630）为基质制备黄芩苷滴丸，以圆整度和重量差异为评价指标，通过正交试验优化制备工艺。结果，最佳处方和制备工艺条件为：黄芩苷、PEG6000、PVPS630质量比为1：9：1，滴制时药料温度80～90℃，滴距6cm，滴速30滴／min，二甲基硅油为冷却剂，冷却温度为10～15℃。制备的滴丸在40min的平均溶出度为86．54％。结论优选的黄芩苷滴丸制备工艺合理可行。能增加药物的溶出度。
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| 关 键 词： | 黄芩苷 滴丸 正交设计 体外溶出度 |
Optimization of Preparation Technology for Baicalin Dropping Pills |
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| Institution: | MAO Liu-jun, CHEN Wei, LIAO Zeng-zhen, ZHAQ ZHi-ying (1. The affiliated Hospital of Guilin Medical College, Guangxi Province, Guilin 541001, China; 2. China Pharmaceutical University, Jiangsu Province, Nanjing 211198, China) |
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| Abstract: | OBJECTIVE To investigate optimal preparation technology of Baicalin Dropping Pills and study its dissolution in vitro. METHODS The baicalin dropping pills were prepared with PEG 6000 and PVP S630 as matrix. Orthogonal design was conducted to explore the influencing factors of baicalin dropping pills by evaluating the indexes of roundness and weight difference. RESULTS The optimal technology conditions were as follows： the ratio of baicalin, PEG 6000 and PVP $630 as 1 ： 9： 1, temperature of dropping drug liquid 80 - 90℃, dropping distance 6cm, dropping speed 30d · min-1, dimethy-silicone oil as eooling agent and the cooling temperature was 10 - 15℃. The average dissolution amount of Baicalin from Dropping Pills was 86.54% at 40min. CONCLUSION The optimized process of Baicalin Dropping Pills is reasonable and feasible, which has a good effect on increasing the drug dissolution. |
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| Keywords: | Baicalin Dripping pill Orthogonal design Dissolution in vitro |
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