阑尾神经内分泌瘤16例临床病理及免疫表型分析

目的探讨阑尾神经内分泌瘤（neuroendocrine tumor,NET）的临床病理、免疫表型及预后特征。方法对1995年1月—2013年12月16例阑尾NET的病历资料进行回顾性分析。结果本组16例平均年龄30岁,女性多于男性。12例临床表现为右下腹痛,14例术前临床诊断为急性阑尾炎。肿瘤细胞形态一致,异型性小,主要形成实性巢岛结构。CD56、NSE及CgA均为阳性,11例Syn阳性。16例分级均为1级（G1）。16例中12例行单纯阑尾切除术,2例行右半结肠切除术,13例（81.2%）平均随访时间为43个月,均无瘤生存。结论阑尾NET好发于中青年,女性多见,术前易误诊为急性阑尾炎,手术是主要治疗方法,预后良好。

Analysis of Clinicopathological Features and Immunophenotype of 16 Patients with Appendiceal Neuroendocrine Tumor

Objective To investigate the clinicopathological features,immunophenotype and prognosis of appendiceal neuroendocrine tumor（ NET）. Methods Clinical data of 16 patients with appendiceal NET during January 1995 and December 2013 was retrospectively analyzed. Results The average age of the 16 patients was 30 years,and there were more female patients. Twelve patients had right lower abdominal pain,and acute appendicitis was preoperatively diagnosed in 14 patients. Tumor cells were uniform in form and lack of atypia,which mainly constituted tight solid nests.The results of immunohistochemistry showed that CD56,NSE and CgA were positive,and Syn was positive in 11 patients. All the 16 patients were Grade 1（ G1）. Single appendectomy was performed in 12 patients,and right hemicolectomy was performed in 2 patients. The average follow-up time in 13 patients（ 81. 2%） was 43 months,and they all survived without the tumor. Conclusion Appendiceal NET is generally found in young and middle-aged people,especially in females.It is easily misdiagnosed preoperatively as acute appendicitis,and surgery is the preferred treatment with good prognosis.