大黄注射液治疗疱疹性皮肤病的临床观察

目的:观察大黄注射液治疗疱疹性皮肤病的临床疗效.方法:157例疱疹性皮肤病患者(其中带状疱疹59例,单纯疱疹98例),分成治疗组117例与对照组40例,治疗组应用大黄注射液每次2 mL,im,qd或bid,皮损局部另用大黄注射液湿敷;对照组给予阿昔洛韦,每次0.1 g,po,qid,皮损局部用0.1%依沙丫啶溶液湿敷,或3%阿昔洛韦软膏外涂.两组均以5 d为1个疗程,未愈者再重复1个疗程.结果:治疗组带状疱疹和单纯疱疹的有效率分别为82.1%和98.7%,对照组有效率分别为85.0%和100.0%;两组疗效差异无显著性(P＞0.05 ),但在疼痛症状的缓解及皮损结痂恢复方面,治疗组明显优于对照组(P＜0.05).结论:大黄注射液治疗带状疱疹和单纯疱疹的疗效好,疗程短,无毒副作用.

Treatment of 117 Cases of Herpetic Dermatosis with Rhubarb Injection

Objective:To survey the clinical therapeutic effectiveness of rhubarb injection in the treatment of herpetic dermatosis. Methods:157 patients with herpetic dermatosis including 59 cases of herpes zoster and 98 of herpes simplex served as the subjects of the study and were randomly divided into 2 groups. 117 patients of the treatment group were given each 2 mL of rhubarb injection I.M., q.d. or b.i.d., supplemented locally with wet dressings with rhubard injection over the skin lesions. 40 patients of the control group were given each 0.1g of acyclovir PO, q.i.d., while skin lesions were treated with dressings soaked with 0.1% ethacridine or local smearing of acyclovir ointment. The course of treatment in both groups lasted 5 days. A second course was ordered if necessary. Results:The effective rates of rhubarb injection in the treatment of herpes zoster and herpes simplex were 82.1%and 98.7%, respectively, while those for herpes zoster and herpes simplex in patients of the control group were 85.0% and 100.0%, respectively. The differences between effective rates of the two groups were not significant (P>0.05). However, the effects with respect to pain relief as well as crust formation and repair of skin lesions were far much better in patients of the treatment group than in those of the control group(P<0.05). Conclusion:Rhubarb injection was shown to have good clinical therapeutic effects in the treatment of herpetic dermatosis. The course of treatment was relatively short, patients' symptoms faded rapidly and no toxic and side effects were encountered.