Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa |
| |
| Authors: | Lim Kuan-Hon Hiraku Osamu Komiyama Kanki Kam Toh-Seok |
| |
| Affiliation: | Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. |
| |
| Abstract: | Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
