| 病毒性心肌炎脾脏淋巴细胞的活化与凋亡 |
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| 引用本文： | 成建定,陈玉川,竞花兰,郭薇,刘水平. 病毒性心肌炎脾脏淋巴细胞的活化与凋亡[J]. 中国病理生理杂志, 2003, 19(3): 361-362 |
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| 作者姓名： | 成建定 陈玉川 竞花兰 郭薇 刘水平 |
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| 作者单位： | 中山大学中山医学院法医病理学教研室, 广东 广州 510080 |
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| 基金项目： | 广东省自然科学基金资助项目 (95 0 3 0 1)，“2 11工程”重点学科建设课题 |
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| 摘 要： | 目的:探索病毒性心肌炎(VMC)发病的脾脏机制。方法: 运用DNA缺口末端标记法、免疫组化技术检测实验组(VMC猝死者, 8例)及对照组(非心性死亡者, 4例)脾组织中细胞凋亡及主要组织相容性复合物(MHC)Ⅱ类抗原的表达情况。结果:实验组脾组织内可见大量的凋亡细胞, 脾组织MHCⅡ类抗原高表达, 动脉周围淋巴鞘MHCⅡ类抗原阳性细胞显著多于对照组;对照组脾组织内罕见凋亡细胞, MHCⅡ类抗原阳性细胞较少, 主要位于动脉周围淋巴鞘外围。结论:VMC患者脾脏免疫细胞的活化与凋亡相伴存在, 其相互作用的失衡很可能与VMC的发病机制密切相关。
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| 关 键 词： | 心肌炎 脾 细胞凋亡 组织相容性复合物Ⅱ类抗原 |
| 文章编号： | 1000-4718(2003)03-0361-02 |
| 收稿时间： | 2002-01-28 |
Activation and apoptosis of spleen lymphocytes in patients with viral myocarditis |
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| CHENG Jian-ding,CHEN Yu-chuan,JING Hua-lan,GUO Wei,LIU Shui-ping. Activation and apoptosis of spleen lymphocytes in patients with viral myocarditis[J]. Chinese Journal of Pathophysiology, 2003, 19(3): 361-362 |
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| Authors: | CHENG Jian-ding CHEN Yu-chuan JING Hua-lan GUO Wei LIU Shui-ping |
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| Affiliation: | Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China |
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| Abstract: | AIM: To explore the role of activation and apoptosis of splenic lymphocytes in the development of viral myocarditis (VMC). METHODS: Apotosis and MHC II antigen of splenic lymphocytes were detected in the VMC group (VMC, death, 8 cases) and control group (non-cardiac death, 4 cases) with TUNEL and immunohistochemistry methods.RESULTS: Compared with the control group, the increased expression of MHC II antigen and apoptosis were found in the splenic lymphocytes in the VMC group. CONCLUSION: These results suggest that the abnormality of the apoptosis/activation of splenic lymphocytes may be involved in the pathogenesis of VMC. |
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| Keywords: | Myocarditis Spleen Apoptosis Major histocompatibility complex II antigen |
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