老年原发性高血压患者晨峰与脉搏波传导速度相关性研究

目的探讨老年高血压患者血压晨峰与颈桡动脉脉搏波传导速度(crPWV)的相关性。方法选择老年原发性高血压患者159例,根据24 h动态血压结果,将患者分为晨峰组(95例)和非晨峰组(64例)。2组行crPWV检测,并测血生化。结果晨峰组crPWV明显高于非晨峰组[(11.5±1.7)m/s vs(9.1±1.6)m/s,P<0.01]。crPWV与血压晨峰(r=0.787.P<0.01)、24 h收缩压(r=0.649,P<0.01)、年龄(r=0.437,P<0.01)、空腹血糖(r=0.293,P<0.05)及LDL-c(r=0.354,P<0.05)呈正相关;以crPWV为应变量,年龄、高血压病程、体重指数、空腹血糖、24 h收缩压及舒张压、LDL-C、TC、TG、HDL-C、血压晨峰为自变量,进行多元线性逐步回归分析,血压晨峰、24 h收缩压、年龄为crPWV独立影响因素。结论血压晨峰与动脉粥样硬化密切相关。

Association between morning blood pressure surge and pulse wave velocity in elderly hypertensive subjects

objective To investigate the association between morning blood pressure(MBPS) and carotid-radial pulse wave velocity(crPWV),in elderly patients with essential hypertension.Method According to the results of 24 h ambulatory blood pressure monitoring,159 patients were divided in to the morning surge groupCMBPS group,n= 95) and non-morning blood pressure surge group(nMBPS group,n = 64).carotid-radial pulse wave velocity,blood glucose and lipid profiles were recorded.Results The crPWV of the MBPS group was significantly higher than that of the nMBPS group[(11.5±1.7)m/s vs(9.1±1.6)m/s,P<0.01].Pearson relation analysis showed that crPWV level positively correlated with MBPS(r=0.787,P<0.01),the average of 24 h SBP (r=0.649,P<0.01),age(r = 0.437,P<0.01),FPG(r = 0.293,P<0.05) and LDL-C(r=0.354, P<0.05);Multiple linear regression showed that MBPS were significant and independent factors for crPWV in elderly patients with essential hypertension.Conclusion The study showed that MBPS was closely related with atherosclerosis in patients with essential hypertension,suggesting it is justified for concurrent inhibition of morning blood pressure surge in the treatment of high blood pressure.