急性心肌梗死患者血脂和高敏C反应蛋白变化的临床意义

目的探讨急性心肌梗死(AMI)患者血脂和高敏C反应蛋白(hs-CRP)变化的临床意义。方法选择158例AMI患者为AMI组,60例健康体检者为对照组,均测定血脂和hs-CRP水平,并将存活的96例和死亡的37例患者治疗前后血脂和hs-CRP进行分析。结果与对照组比较,AMI组hs-CRP明显升高(P<0.01),TC、TG和LDL-C明显降低(P<0.05),HDL-C虽降低,但差异无统计学意义(P>0.05)。与治疗前比较,治疗后存活患者hs-CRP明显降低(P<0.05),TC、TG、HDL-C和LDL-C升高(P<0.05);而死亡患者hs-CRP明显升高(P<0.01),TC、TG、HDL-C和LDL-C明显降低(P<0.05)。存活者与死亡者血脂和hs-CRP比较,差异有统计学意义(P<0.05,P<0.01)。结论 AMI患者血脂和hs-CRP早期即出现异常改变,其持续性改变与病情变化相关,并有利于观察治疗和判断预后。

Clinical significance of changes in levels of blood lipid and hs-CRP in patients with acute myocardial infarction

Objective In order to study the clinical significance of changes of levels of blood lipid and hs-CRP for the therapy and prognosis of acute myocardial infarction(AMI).Methods The blood lipid(TC,TG,HDL-C and LDL-C) and hs-CRP levels were measured in 158 patients with AMI and 60 controls.Results Serum hs-CRP levels in 158 patients with AMI were significantly higher than those in 60 controls(P<0.01).In blood lipid,serum TC,TG and LDL-C levels in 158 patients with AMI were significantly lower than those in 60 controls(P< 0.05),but serum HDL-C was a little lower.Serum hs-CRP levels after therapy in 96 survived patients with AMI were significantly lower than those before therapy(P<0.05),but in 37 died patients with AMI were significantly increased(P<0.01).Serum TC,TG,HDL-C and LDL-C levels after therapy in 96 survived patients were significantly higher than those before therapy(P<0.05) and covered to normal levels,but in 37 died patients were continually decreased and significantly lower(P< 0.05).Conclusion The blood lipid and hs-CRP were abnormal in early perid of AMI patients.It was concluded that the continual changes were related disease condition,but observation therapy and predicts prognosis.