| 老年前列腺癌去势治疗对血清脂联素及胰岛素抵抗的影响 |
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| 引用本文： | 周 萍,富 路,王秋军,等. 老年前列腺癌去势治疗对血清脂联素及胰岛素抵抗的影响[J]. 中华老年多器官疾病杂志, 2011, 10(5): 408-411. DOI: 10.3724/SP.J.1264.2011.00033 |
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| 作者姓名： | 周 萍 富 路 王秋军 等 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院老年病科,哈尔滨,150086
2. 哈尔滨医科大学附属第一医院心内三科,哈尔滨,150001 |
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| 摘 要： | 目的探讨内源性睾酮缺失对血清脂联素（Adip）及胰岛素抵抗（IR）的影响。方法观察32例老年前列腺癌睾丸全切患者与30例前列腺次全切或全切以及30例正常对照组患者的空腹血糖（FPG）、胰岛素（ISN）和C肽、血清Adip以及IR指数（HOMA-IR）和胰岛素敏感指数（QUICKI）。结果去势组Adip水平较正常对照组明显降低[（1.43±0.79）vs（2.38±0.77）mg/L,P〈0.05],HOMA-IR明显高于正常对照组[（1.75±4.84）vs（1.10±3.45）,P〈0.01];总睾酮与ISN（r=-0.17,P=0.043）、C肽（r=-0.249,P=0.32）和HOMA-IR（r=-0.781,P〈0.01）呈负相关,与Adip水平（r=0.819,P〈0.01）和QUICK（r=0.420,P=0.026）呈正相关。结论内源性睾酮缺乏可能通过对IR及Adip水平的影响参与调节男性心血管疾病的发生发展。
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| 关 键 词： | 前列腺癌 去势 脂联素 胰岛素抵抗 |
Effects of castration on serum Adiponectin level and insulin resistance in patients with prostate carcinoma |
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| ZHOU Ping,FU Lu,WANG Qiujun,et al. Effects of castration on serum Adiponectin level and insulin resistance in patients with prostate carcinoma[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2011, 10(5): 408-411. DOI: 10.3724/SP.J.1264.2011.00033 |
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| Authors: | ZHOU Ping FU Lu WANG Qiujun et al |
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| Affiliation: | ZHOU Ping~(1*),FU Lu~2,WANG Qiujun~1,MENG Jia~1,ZHU Xiuying~1 (1 Department of Geriatrics,Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China,2 Department of Cardiology,First Affiliated Hospital,Harbin 150001,China) |
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| Abstract: | Objective To determine the effects of testosterone deprivation therapy on Adiponectin(Adip) level and insulin resistance (1R) in patients with prostate cancer.Methods The levels of fasting plasma glucose(FPG),insulin(lSN),C-peptide(CP),total testosterone(TT).free testosterone(FT),Adip.insulin resistance(HOMA-IR) and quantitative insulin-sensitivity check index(QUICKI) were measured in 32 patients with prostatic carcinoma under castration(CAS group),30 patients with prostate hypertrophy under total or subtot... |
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| Keywords: | prostatic carcinoma castration Adiponectin insulin resistance |
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