急性脑梗死患者血浆同型半胱氨酸与血小板活化的相关性研究

目的观察急性脑梗死患者血浆同型半胱氨酸(Hcy)、血小板活化指标P选择素、血栓烷B2水平及相互关系,从而研究高同型半胱氨酸(HHcy)血症促进脑梗死发生的机制。方法选择急性脑梗死患者(脑梗死组)466例,再将脑梗死组分为HHcy患者345例和非HHcy患者121例;另选择健康体检者62例为对照组。检测Hcy、P选择素、血栓烷B_2水平,比较Hcy与P选择素、血栓烷B_2的相关性。结果与对照组比较,脑梗死组患者血浆Hcy、P选择素、血栓烷B_2水平明显升高(P<0.05);与非HHcy患者比较,HHcy患者P选择素、血栓烷B_2水平明显升高(P<0.05);脑梗死组、HHcy患者Hcy与P选择素、血栓烷B_2呈正相关(r=0.223,r=0.195,r=0.227,r=0.151,P<0.05);非HHcy患者Hcy与P选择素、血栓烷B_2无相关性。结论 HHcy是脑梗死的危险因素,它可能通过激活血小板的途径导致血栓形成。

Correlation between blood plasm homocysteine and platelet activation in the patients with acute cerebral infarction

Objective To study the mechanism of hyperhomocysteinemia(HHcy) to facilitate acute cerebral infarction by observing the levels of blood plasm homocysteine(Hcy),P-selectin and thromboxaneB_2(TXB_2) and their relationship.Methods 466 acute cerebral infarction patients were divided into 3 groups-HHcy(n=345) and non-HHcy(n=121),and normal control(n=62), and the levels of Hey,P-selectin and TXB_2 in the three groups were compared.The correlation between Hcy,P-selectin and TXB_2 were studied in the three groups.Results The levels of Hcy, P-selectin and TXB2 in cerebral infarction patients were higher than in the control group(P< 0.05).The levels of P-selectin and TXB_2 in HHcy group were higher than in non-HHcy group (P<0.05).Hcy was correlated with P-selectin and TXB_2 in cerebral infarction patients and HHcy group(r=0.223,r = 0.195,r=0.227,r=0.151,P<0.05),but not in non-HHcy group. Conclusions HHcy was the risk factor of cerebral infarction.Possibly,HHcy activated platelet and resulted in thrombogenesis.