| p75 神经营养因子受体在心血管系统中的作用 |
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| 引用本文： | 蓝云锋,李泱. p75 神经营养因子受体在心血管系统中的作用[J]. 中华老年多器官疾病杂志, 2011, 10(3): 286-288 |
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| 作者姓名： | 蓝云锋 李泱 |
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| 作者单位： | 解放军总医院老年心血管病研究所,北京,100853 |
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| 摘 要： | p75神经营养因子受体属于神经营养因子的受体之一。越来越多的研究表明,p75NTR在心血管系统自主神经中发挥重要的作用,不仅促进交感神经的生长发育,还调节心脏神经递质的释放。p75NTR还抑制新生血管形成,具有一定的抗血管生成作用,且介导平滑肌细胞凋亡,加重血管粥样硬化损伤。p75NTR这些特性表明其抑制剂存在重要的治疗潜能,或许能够改善缺血所致的损伤,如冠心病、急性心肌梗死、周围血管病变等。
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| 关 键 词： | p75NTR 交感神经 动脉粥样硬化 心室重构 |
Roles of p75 neurotrophin receptor in cardiovascular system |
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| LAN Yunfeng,LI Yang. Roles of p75 neurotrophin receptor in cardiovascular system[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2011, 10(3): 286-288 |
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| Authors: | LAN Yunfeng LI Yang |
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| Affiliation: | LAN Yunfeng,LI Yang (Institute of Geriatric Cardiology,Chinese PLA General Hospital,Beijing 100853,China) |
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| Abstract: | p75 neurotrophin receptor(p75NTR) is one of the neurotrophins receptors.Many studies have indicated that p75NTR plays an important role in the cardiovascular autonomic nervous system,such as promoting growth and development of sympathetic nerve,regulating cardiac neurotransmitter release.P75NTR have showed the strong anti-neovascularization effect in a mouse model of limb ischemia,so-called anti-angiogenic action.It was demonstrated that p75NTR was an inducer of smooth muscle cell apoptosis in atherosclerot... |
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| Keywords: | p75NTR sympathetic nerve atherosclerosis ventricular remodeling |
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