血浆置换治疗急性重度有机磷农药中毒的Meta分析

目的 探讨血浆置换(PE)治疗急性重度有机磷农药中毒( AOPP)的疗效.方法 检索中国学术期刊全文数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM),收集PE治疗AOPP的队列研究,采用Review Manager 4.2分析软件进行固定效应模型的Meta分析.结果 入选的6项研究中共包括AOPP患者433例,其中治疗组211例,均为常规内科治疗加PE;对照组222例,均为常规内科治疗.治疗组患者病死率[9.00％( 19/211)]明显低于对照组[28.38％( 63/22)],差异有统计学意义(RR为0.30,95％CI为0.19～0.49,P＜0.01).结论 PE可降低AOPP的病死率.

Meta-analysis of the effectiveness of plasma exchange in treatment of severe and acute organophosphate poisoning

Objective To discuss the effectiveness of severe and acute organophosphate poisoning (AOPP) treated with plasma exchange in China.Methods Researches about effectiveness of severe AOPP treated with plasma exchange were analyzed by Review Manager 4.2 and fixed effect model of meta-analysis method were used.Results Six trials including 433 patients were identified.Treatment group including 211 patients adopted traditional physician therapy plus plasma exchange,and control group including 222 patients received physician therapy only.The case-fatality rate of the treatment group was lower than the control one [RR=0.30,95％CI (0.19～0.49),P＜0.01].Conclusion Plasma exchange can improve the cure rate of severe AOPP.