趋化因子CXCL10临床研究现状

CXC趋化因子配体10(CXCL10)属于CXC趋化因子超家族的非ELR类,参与多种自身免疫性疾病。它不仅可以趋化白细胞向炎症部位聚集,而且可以减少肿瘤组织的血液供应,抑制肿瘤生长;同时CXCL10及其受体CXCR3在肝脏炎症、甲状腺滤泡上皮细胞及浸润的炎性细胞中表达均显著增高。现着重对趋化因子CXCL10及其受体的结构、生物学功能及与疾病的关系予以综述。

Current Research of CXC Chemokine Ligand-10

CXC chemokine ligand-10 belongs to the family of non-ELR-CXC chemokine,which participates in many autoimmune diseases.It can not only recruit specific subtypes of leukocytes to inflammation sites,but also reduce the blood supply to tumors and inhibit the growth of tumor.Meanwhile,CXCL10 and its receptor CXCR3 are significantly increased in liver inflammation,thyroid follicular epithelial cells and infiltration of inflammatory cells.This article reviewed the structure,biological function and the relationship of CXC chemokine ligand-10 and its receptor with multiple diseases.