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| VEGF和MMP-2表达与肝细胞肝癌复发和预后的关系 | |
| 引用本文： | 赵秀兰,杜静,赵学铭,沈军,倪春生,赵楠,孙保存.VEGF和MMP-2表达与肝细胞肝癌复发和预后的关系[J].中国肿瘤临床,2008,35(16):934-937. |
| 作者姓名： | 赵秀兰 杜静 赵学铭 沈军 倪春生 赵楠 孙保存 |
| 作者单位： | 1. 天津医科大学病理教研室,天津市,300070 2. 天津市中心妇产科医院病理科 3. 天津医科大学病理教研室;天津医科大学附属肿瘤医院 |
| 基金项目： | 天津市科委资助项目，天津市教委资助项目 |
| 摘 要： | 目的：研究血管内皮生长因子（VEGF）和基质金属蛋白酶2（MMP-2）在肝细胞肝癌（HCC）中的表达与HCC复发转移的关系。方法：按是否复发将93例肝癌患者分为复发组与未复发组，采用免疫组化方法检测两组标本中VEGF及MMP-2的表达情况，分析两者的表达与临床病理指标的关系。结果：VEGF与MMP-2在93例HCC中的阳性表达率分别为52．69％与67．74％，复发组（44例）的阳性表达率分别为68．18％（30／44）、88．64％（39／44）；未复发组（49例）的阳性表达率分别为36．78％（19／49）、48．98％（24/49），两组之间差异具有统计学意义（P〈0．05）。生存分析显示术后两年生存率MMP-2（＋）与（-）组分别为41．42％、63．36％，差异具有统计学意义（P〈0．05）；VEGF（＋）与（-）两年生存率分别为48．50％、52．21％，差异不具有统计学意义（P〉0．05）。结论：MMP-2表达高的肝癌，转移复发率高，预后差。 |
| 关 键 词： | 血管内皮生长因子 基质金属蛋白酶2 肝细胞癌 |
Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Hepatocellular Carcinoma and Its Relationship with Rucurrence and Prognosis |
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| ZHAO Xiulan,DU Jing,ZHAO Xueming,SHEN Jun,NI Chunsheng,ZHAO Nan,SUN Baocun.Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Hepatocellular Carcinoma and Its Relationship with Rucurrence and Prognosis[J].Chinese Journal of Clinical Oncology,2008,35(16):934-937. | |
| Authors: | ZHAO Xiulan DU Jing ZHAO Xueming SHEN Jun NI Chunsheng ZHAO Nan SUN Baocun |
| Institution: | ZHAO Xiulan,DU Jing,ZHAO Xueming,SHEN Jun,NI Chunsheng,ZHAO Nan,SUN BaocunDepartment of Pathology,Tianjin Medical University,Tianjin 300070,China |
| Abstract: | Objective: To investigate the expression and clinical impact of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 2 (MMP-2) in hepatocellular carcinoma (HCC). Methods: We collected 93 HCC resection samples with complete clinical and prognostic data. Immunohistochemical staining of VEGF and MMP-2 were conducted in recurrent group (44) and non-recurrent group (49). Correlations of the expression of MMP-2 and VEGF with clinicopathologic features were analyzed. Results: The positive rates o... |
| Keywords: | Vascular endothelial growth factor Matrix metalloproteinase 2 Hepatocellular carcinoma |
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