| 重组活化因子Ⅶ在难治性产后出血中的应用 |
| |
| 引用本文： | 廖秋萍（综述）,颜建英（审校）. 重组活化因子Ⅶ在难治性产后出血中的应用[J]. 国外医学:妇产科学分册, 2010, 37(4): 245-248,256 |
| |
| 作者姓名： | 廖秋萍（综述） 颜建英（审校） |
| |
| 作者单位： | [1]福建医科大学研究生学院,福州350004 [2]福建医科大学教学医院福建省妇幼保健院妇产科,福州350004 |
| |
| 摘 要： | 产后出血是全球最常见孕产妇死亡原因之一。重组活化因子Ⅶ（rFⅦa）已成功应用于有凝血因子Ⅷ或Ⅸ抑制物的血友病患者,并用于其他凝血酶生成障碍性出血性疾病患者。近年也有研究表明,rFⅦa在治疗外伤、外科相关事件导致的严重出血,甚至在妇产科出血等非血友病的出血方面起到更广泛作用。现就rFⅦa在难治性产后出血中的临床应用进展进行综述。
|
| 关 键 词： | 产后出血 重组蛋白质类 凝血酶 治疗 |
The Use of Recombinant Activated Factor VII in Intractable Postpartum Haemorrhage |
| |
| Affiliation: | LIAO Qiu-ping, YAN Jian-ying. Postgraduate Institue of Fujian Medical University,Fuzhou 350004, China( LIAO Qiu-ping); Department of Gynecology and Obstetrics ,Fujian Medical University Teaching Hospital Fujian Maternity and Child Health Hospital, Fuzhou 350001, China( YAN Jian-ying) |
| |
| Abstract: | Postpartum haemorrhage is one of the most common causes of maternal death worldwide. Recom- binant activated factor Ⅶ（rFⅦa ） has already been successfully used for the treatment of bleeding episodes in patients with hemophilia A or B with formation of inhibitiors to factor Ⅷ or factor Ⅸ after replacement therapy and in other partients with inhibition of thrombin generating. Recently, scholars have found that rFⅦa plays wider roles in treating haemorrhage in patients with trauma, major surgery and even intractable obstetric and gynaecological hem- orrhage. This article reviews the progress in the use of rFⅦa in intractable postpartum haemorrhage. |
| |
| Keywords: | Postpartum hemorrhage Recombinant proteins Thrombin Therapy |
| 本文献已被 维普 等数据库收录！ |
|
