山东地区解脲脲原体抗菌药物敏感性检测

目的 探讨近年来山东地区解脲脲原体抗菌药物敏感性变化趋势。 方法 对本科近6年来3984例门诊患者进行解脲脲原体培养，阳性的患者进行药物敏感性试验。 结果 Uu对喹诺酮类药物耐药严重，最高的环丙沙星耐药率接近90%。耐药率较低的药物包括四环素、美满霉素、强力霉素、克拉霉素和交沙霉素。罗红霉素和阿奇霉素的耐药率近年来有较明显的上升。 结论 山东地区Uu对喹诺酮类药物耐药严重，不宜作为经验性用药。为减少耐药性产生，宜根据药敏试验的结果足量、足疗程使用抗菌药物。在无药敏结果参考时，可以采用满霉素、强力霉素、克拉霉素及交沙霉素进行治疗。

Antimicrobial susceptibility tests of clinical isolates of Ureaplasma urealyticum from Shandong region

Objective To discuss the trends in the rates of resistance of Ureaplasma urealyticum to antibiotics in Shandong patients. Motheds The Uu culture were done in 3984 out patients and drug sensitivity tests were done when the culture result was positive. Results Uu strongly resisted to quinolones, the resistance rate to ciprofloxacin was nearly 90%. Tetracycline, minocin, deoxycycline, clarithromycin and josamycin had low resistance rate. The resistance rate of roxithromycin and azithromycin rose obviously in recent years. Conclusion Uu resisted to quinolones, can’t be chosen as experiential drug. It’s better to use correct dosage and period based upon the drug sensitive tests. Minocin, deoxycycline, clarithromycin and josamycin could be chosen as experiential when drug sensitive tests are not available.