| Abstract: | From 1973 t0 1979 156 cases of hemorrhagicfever (HF) were treated with endoxan. Immu-nologic studies showed enhancement of humoralimmunity, decrease of serum complement andsuppression of cellular immunity, all of whichappeared early in the course of the! disease. Cir-culating immune complexes (CIC) were found atthe same trime. Renal biopsy revealed that im-mune complexes (lC) were present on glomerulibasement membrane. Good clinical responsewas noted upori early inst.itut.ion of endoxantherapy, more than 90To of the patients did notgo through the stages of hypotension and/oroliguria. The pathogenesis of the disea.se isbriefly discussed. |
