| 二甲亚砜和维甲酸对人卵巢癌细胞COC-1的逆转作用研究 |
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| 引用本文： | 李从荣,李爱林,左武,姚学军. 二甲亚砜和维甲酸对人卵巢癌细胞COC-1的逆转作用研究[J]. 武汉大学学报(医学版), 1997, 0(2) |
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| 作者姓名： | 李从荣 李爱林 左武 姚学军 |
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| 作者单位： | 基础医学院病毒研究所 |
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| 摘 要： | 以人卵巢癌细胞株ＣＯＣ－１为模型，观察了诱导分化剂二甲亚砜（ＤＭＳＯ）与维甲酸（ＲＡ）对该细胞生长增殖、ＤＮＡ合成和超微结构的影响。结果显示：ＤＭＳＯ和ＲＡ可明显抑制ＣＯＣ－１细胞的生长和ＤＮＡ合成，并改变其恶性细胞的结构特征，使之向正常细胞的方向逆转，从而提示ＤＭＳＯ和ＲＡ对人卵巢癌细胞有一定的诱导分化作用。
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| 关 键 词： | 二甲亚砜；维甲酸；诱导分化；超微结构 |
The Effects of Reverse of DMSO and RA on Human Ovarian Cancer Cell COC 1 |
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| Li Congrong,Li Ailin,Zuo Wu,et al. The Effects of Reverse of DMSO and RA on Human Ovarian Cancer Cell COC 1[J]. Medical Journal of Wuhan University, 1997, 0(2) |
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| Authors: | Li Congrong Li Ailin Zuo Wu et al |
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| Abstract: | The effects of DMSO and RA on cell growth and ultrastructure in the cell were studied by using ovarian cancer cell COC 1 as a model. The results showed that the proliferation and DNA synthesis of COC 1 cell was significantly inhibited by DMSO or RA, DMSO or RA which can change the structural characteristic of COC 1 cell from malignant state to differentiated one. It is suggested that DMSO and RA have the ability to induce differentiation of human ovarian cancer cell. |
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| Keywords: | dimethyl sulfoxide retinoic acid differentiation ultrastructure |
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