cyclinD1、p16、Rb在胸腺瘤中表达及预后意义

目的：探讨ｃｙｃｌｉｎ Ｄ１、ｐ１６、Ｒｂ蛋白在胸腺瘤中表达及预后意义。方法；应用免疫组化Ｓ－Ｐ法，对５４例胸腺瘤标本进行检测。结果：ｃｙｃｌｉｎＤ１、ｐ１６，Ｒｂ蛋白在髓质型，混合型胸腺瘤中阳性表达率分别为２３．１％（３／１３）、６９．２％（９／１３），５３．９％（７／１３），器官样，普通皮质型胸腺瘤中阳性表达率分别为５０．０％（８／１６）、７５．０％（１２／１６）、７５．０％（１２／１６），高

Signification relationships prognosis and expression of cyclinD1 , p16 and Rb in thymoma

Purpose To explore the expression and significance of cyclinD1, p16 and Rb protein in thymoma. Methods Immunohistochemical method was used for examinating the sections from 54 thymomas. Results The positive rates of cyclinD1, p16 Rb were 23 1%(3/13),69 2%(9/13),53 9%(7/13) in the medullary and mixed thymoma. The positive rates of were 50 0%(8/16), 75 0%(12/16),75 0%(12/16) in the cortical. The positive rates of were 84 0%(21/25), 40 0%(10/25),56 0%(14/25), in the well differentiated thymic carcinoma and well grede thymic carcinoma; respectively, ( P <0 05 ). The positive rates of cyclinD1, p16 and Rb protein had relation with the histologic subtyping, clinical stage and prognosis in the thymoma. Conclusion cyclinD1, p16 and Rb protein are involved in cell proliferating and influence differentiation of thymoma,which can be adapted as an useful index for prognosis monitoring.