The Maudsley family study I: Structural brain changes on magnetic resonance imaging in familial schizophrenia期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The Maudsley family study I: Structural brain changes on magnetic resonance imaging in familial schizophrenia

Authors:	Tonmoy Sharma George Du Boulay Shon Lewis Thordur Sigmundsson Hugh Gurling Robin Murray

Affiliation:	^a Department of Psychological Medicine, Institute of Psychiatry, London, U.K. ^b Department of Neuroradiology Institute of Neurology, London, U.K. ^c Department of Psychiatry University of Manchester, Manchester, U.K. ^d Molecular Psychiatry Laboratory, Department of Psychiatry, University College London Medical School, London, U.K.

Abstract:	1. 1. The authors investigated the prevalence of qualitatively rated structural brain abnormalities in schizophrenic probands and their first-degree relatives from families multiply affected with schizophrenia. 2. 2. Magnetic resonance imaging was used to evaluate brain morphology in 33 schizophrenic probands, 54 of their non-schizophrenic first-degree relatives (including 11 presumed obligate carriers) and 37 unrelated control subjects. Structural images were examined by a neuroradiologist who was blind to diagnostic and family status. 3. 3. 52% of the schizophrenic subjects were rated as showing abnormalities compared with 27% of presumed obligate carriers, 16% of their non-schizophrenic relatives and 11% of unrelated controls. 4. 4. Brain abnormalities were more frequent in schizophrenic subjects from multiplex families than in their first-degree relatives and controls. Abnormalities were also found in unaffected relatives particularly those who appear to be transmitting the disorder.

Keywords:	Magnetic Resonance Imaging schizophrenia familial genetics brain imaging
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