四种血清肿瘤标志物联合检测对大肠癌临床意义的探讨

目的：探讨CEA、CA19-9、CA242和CA72-4四项血清肿瘤标志物在大肠癌的诊断、手术疗效评价和术后检测的临床价值。方法 应用免疫放射分析法测定80例大肠癌患者和50例大肠良性疾病患者的CEA、CA19-9、CA242和CA72-4等4项血清肿瘤标志物，并随访2年。结果 4种血清肿瘤标志物CEA、CA19-9、...

Four kinds of serum tumor markers combined detection: the clinical value in colorectal cancer

Objective To investigate the clinical value of CEA, CA19-9, CA242 and CA72-4 four serum tumor markers in colorectal cancer diagnosis, surgery and postoperative evaluation of their. Methods Immunohistochemical assay was used in 80 patients with colorectal cancer and 50 cases of colorectal benign diseases to detect the CEA, CA19-9, CA242 and CA72-4 and other four serum tumor markers, with 2-year follow- up. Results Four kinds of serum tumor markers CEA, CA19-9, CA242 and CA72-4 levels in colorectal cancer group were significantly higher than the control group ( P ＜ 0.05 ) ; levels of the four serum tumor markers in patients in Dukes stages C, D were significantly higher than those in Dukes stages A, B;four serum tumor markers were significantly increased in patients with recurrence of metastasis. Conclusion Combined detection of serum CEA, CA19-9, CA242 and CA72-4 has clinical value in diagnosis, surgical treatment evaluation and monitoring of metastasis and recurrence after surgery of colorectal cancer can improve detection sensitivity and specificity.