p16 and Ki67 expression in normal,dysplastic and neoplastic uterine cervical epithelium and human papillomavirus (HPV) infection |
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| Authors: | L.N. Calil M.I.A. Edelweiss L. Meurer C.N. Igansi M.C. Bozzetti |
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| Affiliation: | 1. Post Graduate Programs in Medical Sciences and Epidemiology, Federal University of Rio Grande do Sul, Brazil;2. School of Pharmacy, Federal University of Rio Grande do Sul, Brazil;3. Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil |
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| Abstract: | Cellular cycle proteins like the p16INK4a and the Ki67 proliferation nuclear antigen have been used as oncogenicity cellular markers. The E6 and E7 oncoproteins interact with tumor suppressor genes p53 and pRb, culminating with the p16INK4a overexpression. |
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| Keywords: | p16INK4a HPV infection Ki67 Cervical cancer |
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