肝病患者肝组织内CMV感染的初步研究

本文应用免疫组织化学方法检测140例急、慢性肝炎患者肝组织内CMV抗原,发现15例阳性(10.7%),有9例同时存在HBV感染,其中3例为三重感染。15例CMV抗原阳性肝炎中,11例为慢性肝炎。以同法检测20例肝细胞性肝癌患者肝组织中CMV抗原,发现1例阳性。结果提示CMV感染为病毒性肝炎的病因之一;CMV肝炎与其他病毒性肝炎及慢性肝脏疾病可同时存在;CMV肝炎可能存在慢性化倾向。

Preliminary Study of Intrahepatic Human CytomegalovirusInfection in Patients with Liver Diseases

Intrahepatic CMV antigen was detected in 140 cases with acute and chronichepatitis and in 20 cases with hepatocellular carcinoma (HCC) by indirect enzyme-labeled technique. Intrahepatic CMV antigen was detected in 15 out of 140 caseswith viral hepatitis, and 1 out of 20 cases with HCC; Hepatitis B virus infectionwas imposed on 9 of the 15 cases with positive CMV antigen, interestingly, 3 outof the 9 cases with HBV superinfection were proved to be victims of multiple-Infection. In histopathology, 11 out of 15 cases with positive CMV antigen werecharacteristic of chronic hepatitis. In addition, CMV antigen positive hepatocyteswere all limited to pseudo--nodules instead of carcinomous tissues in 1 case withHCC. All finding suggested that CMV infection could be one of the responsibleagents for viral hepatitis in China; CMV associated hepatitis could he coexistedwith HBV as well as other chronic liver diseases, leading to chronicity of the di-sease.