血清PSAD和PSA对前列腺上皮内瘤的早期诊断价值

目的 研究血清中前列腺特异性抗原密度（PSAD）和前列腺特异性抗原（PSA）对前列腺上皮内瘤的早期诊断价值.方法 采用酶联免疫法（ELISA）对我院138例前列腺上皮内瘤患者的PSA进行测定,用超声诊断仪测定前列腺的体积,并计算出PSAD.结果 前列腺上皮内瘤组PSA值和PSAD值分别为为（61.41±40.9） ng/ml和（1.18±0.89）,良性前列腺增生组PSA值和PSAD值分别为为（8.63±4.36） ng/ml和（0.13±0.14）,两组的PSA和PSAD均有显著差异,均P＜0.05,具有统计学意义.前列腺上皮内瘤组PSA多分布于大于20 ng/ml,占总数62.30%,PSAD多数＞0.15,占总数88.52%,良性前列腺增生组PSA多分布于4-20 ng/ml之间,占总数的55.84%,PSAD多数≤0.15,占总数48.05%,前列腺上皮内瘤组PSA值和PSAD值分别为（13.15±5.98） ng/ml和（0.49±0.31）,良性前列腺增生组PSA值和PSAD值分别为为（7.84±3.54） ng/ml和（0.15±0.11）,两组的PSA和PSAD均有显著差异,均P＜0.05,具有统计学意义.PSA＞4 ng/ml,PSAD＞0.15时患有前列腺上皮内瘤的敏感性和特异性升高,特别是PSA在4-20 ng/ml区间时.结论 测定血清中PSA含量并计算PSAD对前列腺上皮内瘤的早期鉴别诊断具有重要意义.

Early Diagnostic Value of PSAD and PSA in Serum to Prostatic Intraepithelial Neoplasia

Objective to study the early diagnostic value of PSAD and PSA in serum to the prostatic intraepithelial neoplasia. Methods 138 patients with prostatic intraepithelial neoplasia were selected to be given PSA examination using ELISA, and then the volumes of their prostates were measured with diasonograph to calculate the PSAD. Results the PSA and PSAD values of the group of. patients with prostatic intraepithelial neoplasia were respectively （61.41 ± 40.9） ng/ml and （1.18±0.89） ,while those values of the group of benign prostatic hyperplasia were respectively （8.63 ±4.36） ng/ml and （0.13±0.14） ; the PSA and PSAD values of the two groups differed greatly,P〈0.05 in both cases,which was of statistic significance. The PSA values in the group of patients with prostatic intraepithelial neoplasia were mostly above 20 ng/mi,accounting for 62.30% of all the measured values and the PSAD values 〉0.15 mostly, accounting for 88.52% of all the measured values; the PSA values of the group of benign prostatic hyperplasia were mostly between 4 and 20 ng/ml,accounting for 55.84% of all the measured values,and the PSAD values ≤0.15 most ly,accounting for 48.05% of all the measured values; the PSA and PSAD values of the group of patients with prostatic intraepithelial neoplasia were respectively （13.15±5.98） ng/ml and （0.49±0.31）,while those values of the group of benign prostatic hyperplasia were respectively （7.84±3.54） ng/ml and （0.15±0.11）; the PSA and PSAD values of the two groups differed obviously,P〈0.05 in both eases, which was of statistic significance. The sensitivity and speci ficity of the prostatic intraepithelial neoplasia is higher when PSA〉4 ng/ml, PSAD〉0. 15, especially when the PSA value is between 4 to 20 ng/ml. Conclusion measuring PSA content in the serum and calculating PSAD is of great sig nificance to the early differential diagnosis of prostatic intraepithelial neoplasia.