炙甘草汤对心律失常气阴两虚证患者心率变异性及炎症因子的影响

目的:观察炙甘草汤对心律失常气阴两虚证患者心率变异性及炎症因子的影响,并探讨其作用机制。方法:将诊断明确的心律失常患者90例,随机分为治疗组(47例)和对照组(43例),对照组给予西医常规治疗加用胺碘酮片,治疗组在对照组基础上辨证服用炙甘草汤加减。两组均治疗8周,比较两组治疗前后心律失常疗效、中医证候积分及疗效、心率变异率(HRV),白细胞介素-6(IL-6),超敏C反应蛋白(hs-CRP)水平。结果:治疗后,治疗组的心律失常疗效指标优于对照组(P0.05);两组治疗后中医症状疗效比较,治疗组总有效率高于对照组(P0.05);同治疗前比较,两组治疗后均能改善中医证候积分,治疗组积分改善程度优于对照组(P0.01);治疗后两组HRV指标均升高(P0.05,P0.01),IL-6,hs-CRP水平均下降(P0.05,P0.01),治疗组HRV,IL-6,hs-CRP改善程度优于对照组(P0.01)。结论:炙甘草汤能提高心律失常临床疗效,调节心律失常患者心率变异性指标,抑制炎症细胞因子,改善患者临床症状,对心律失常患者心脏自主神经病变及炎症损伤具有修复作用。

Effect of Zhigancao Tang on Heart Rate Variability and Inflammatory Factors in Patients with Cardiac Arrhythmia with Qi-Yin Deficiency

Objective: To observe the effect of Zhigancao Tang on heart rate variability and inflammatory factors in patients with cardiac arrhythmia with Qi-Yin deficiency. Method: A total of 90 patients with definite arrhythmia were randomly divided into treatment group (47 cases) and control group (43 cases). The control group received routine Western medicine plus amiodarone tablets, and treatment group was treated with Zhigancao Tang in addition to the therapy of control group. Both groups were treated for 8 weeks, and their arrhythmia efficacy, traditional Chinese medicine (TCM) symptom score and efficacy, heart rate variability (HRV), interleukin-6 (IL-6), and high sensitivity C-reactive protein (hs-CRP) indicators were compare. Result: After treatment, the therapeutic effect of arrhythmia in treatment group was better than that in control group (P<0.05). According to the comparison of TCM syndromes between two groups after treatment, the total effective rate in treatment group was higher than that in control group (P<0.05). Compared with before treatment, both groups could improve TCM symptom scores, and the score of improvement in treatment group were better than that in control group (P<0.01). After treatment, HRV in both groups was increased (P<0.05, P<0.01), while IL-6 and hs-CRP were decreased in both groups (P<0.05, P<0.01), the improvements of HRV, IL-6 and hs-CRP in treatment group were better than that in control group (P<0.01). Conclusion: Zhigancao Tang can improve the clinical efficacy of arrhythmia, regulate heart rate variability, inhibit inflammatory cytokines, improve clinical symptoms and repair cardiac autonomic neuropathy and inflammatory injury in patients with arrhythmia.