不同胎龄早产儿喂养不耐受影响因素分析

目的 探讨不同胎龄早产儿喂养不耐受的影响因素。方法回顾性调查分析胎龄小于等于32周早产儿102例和胎龄大于32周早产儿362例,单因素和多因素Logistic回归分析某些高危因素(母体异常、胎盘脐带异常、宫内窘迫、胎膜早破、分娩方式、产期使用糖皮质激素情况、围生期感染、呼吸暂停、机械通气等)与不同胎龄早产儿发生喂养不耐受的相关性。结果小于等于32周组早产儿与大于32周组早产儿中喂养不耐受的发生率分别为41.18%和22.38%,两者显著差异(P<0.05)。多因素Logistic分析显示,小于等于32周组早产儿发生喂养不耐受的影响因素有:产前应用糖皮质激素、呼吸暂停、机械通气；大于32周组早产儿发生喂养不耐受的影响因素有:胎膜早破、围生期感染、呼吸暂停。结论不同胎龄早产儿发生喂养不耐受的影响因素不完全相同,临床防治工作中应有所区别。

Factors affecting feeding intolerance in preterm infants of different gestational ages

Objective To investigate the factors affecting feeding intolerance(FI) in the preterm infants of different gestational ages.MethodsA retrospective investigation method was used to analyze the 102 preterm infants at the gestational ages of less than or equal to 32 weeks and 362 preterm infants at the gestational ages of over 32 weeks.Some possible relevant risk factors were analyzed by simple-factor analysis;Binary Logistic regression was performed to determine factors of FI in the preterm infants during different gestational ages.ResultsThe incidence rates of FI in the preterm infants during different gestational ages were 41.18% and 22.38%,and the difference of both was significant (P<0.05).Multiple Logistic regression analysis showed that using of glucocorticoids in antepartum,apnea,mechanical ventilation were the factors of FI in preterm infants at the gestational ages of less than or equal to 32 weeks,and that premature rupture of membranes,perinatal infections,apnea were the factors of FI in preterm infants at the gestational ages of over 32 weeks.ConclusionsThe factors of FI in the preterm infants during different gestational ages were not all the same.We should treat them differently in the clinical work.