药食心葆汤对心血瘀阻证冠心病患者血清同型半胱氨酸及凝血功能的影响

目的:观察药食心葆汤联合西药治疗冠心病的临床疗效及其对血清同型半胱氨酸(homocysteine,HCY)水平凝血功能的影响,并探讨其作用机制。方法:选取2015年1月至2016年1月于郑州市中医院心内科入院治疗并确诊为心血瘀阻证的冠心病患者200例,按照随机数字表法分为对照组和观察组,对照组102例,观察组98例,对照组患者采用常规西药治疗,观察组在此基础上联合药食心葆汤治疗,药物干预治疗8周,比较两组患者血清同型半胱氨酸(HCY),凝血功能[凝血酶原时间(prothrombin time,PT),部分凝血活酶时间(activated partial thromboplastin time,APTT),纤维蛋白原(fibrinogen,FIB)]等指标。结果:治疗后观察组患者凝血功能、血清HCY水平改善程度优于对照组(P0.05);观察组可明显降低CHD患者血清HCY水平(P0.05),调节患者的凝血功能(P0.05),组间比较显示两组有明显差别,特别是在改善凝血功能方面,观察组明显优于对照组(P0.05),对照组治疗前后各项指标没有统计学差异。结论:药食心葆汤联合西药治疗冠心病的临床疗效确切,能有效降低CHD患者HCY水平、调节凝血功能,值得临床推广使用。

Effect of Yaoshi Xinbao Decoction on Serum Homocysteine and Blood Coagulation Function in Patients with Blood Stasis Syndrome Coronary Heart Disease

Objective: To investigate the clinical efficacy of Yaoshi Xinbao decoction combined with western medicine in the treatment of coronary heart disease and observe its effect on serum homocysteine (HCY) level and blood coagulation function. Method: The 200 patients with blood stasis syndrome coronary heart disease from January 2015 to January 2016 in Department of cardiology of our hospital were randomly divided into control group (102 cases) and observation group (98 cases). Patients in control group were treated with conventional western medicine, and patients in observation group received additional Yaoshi Xinbao decoction based on the treatment in control group for 8 weeks. The two groups of patients were compared for serum homocysteine (HCY) and coagulation function (prothrombin time, activated partial thromboplastin time, fibrinogen). Result: The improvement degree of coagulation function and serum HCY level in observation group was better than that in control group after treatment (P<0.05); observation group could significantly reduce the serum HCY level in patients with CHD (P<0.05), and regulate the blood coagulation function (P<0.05), with significant differences between the groups, especially in the improvement of coagulation function (P<0.05). Control group had no significant differences before and after treatment. Conclusion: Yaoshi Xinbao decoction combined with western medicine has clear clinical curative effect in treatment of coronary heart disease, which can effectively reduce the level of HCY in CHD patients and regulate blood coagulation function, so it is worthy of clinical promotion.