The effect of corticotrophin and corticosteroids on the external secretion of the pancreas in dogs

In acute experiments in dogs cortisone and hydrocortisone increase the concentration and output of bicarbonate in pancreatic secretion whereas prolonged administration of these hormones leads to a diminished bicarbonate response. In both acute and chronic experiments, however, cortisone and hydrocortisone produce an increased output of the enzymes amylase and trypsin.