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| 白僵菌转化的一个新蒽醌苷类化合物 | |
| 引用本文： | 殷志琦,王磊,叶文才,张健,周长林,赵守训.白僵菌转化的一个新蒽醌苷类化合物[J].中国天然药物,2008,6(2):103-104. |
| 作者姓名： | 殷志琦 王磊 叶文才 张健 周长林 赵守训 |
| 作者单位： | 1. 中国药科大学天然药物化学教研室,南京,210009 2. 中国药科大学天然药物化学教研室,南京,210009;暨南大学中药及天然药物研究所,广州,510632 3. 江苏省中医药研究院,南京,210028 4. 中国药科大学生命科学与技术学院,南京,210009 |
| 摘 要： | 目的：研究白僵菌对大黄酸葡萄糖甲基化的转化作用。方法：在白僵菌培养液中加入大黄酸底物，利用生长细胞对其进行生物转化。发酵液离心后用乙酸乙酯萃取，乙酸乙酯萃取部位通过各种色谱方法分离得到一个新化合物。运用氢谱碳谱以及二维核磁共振光谱鉴定结构。结果：转化产物为大黄酸糖基化衍生物，结构鉴定为7-O-（4’-甲氧基-β—D-葡萄糖）。结论：芦荟大黄素（1）是一个新化合物。 |
| 关 键 词： | 白僵菌 大黄酸 糖基化 |
| 文章编号： | 1672-3651(2008)02-0103-02 |
| 修稿时间： | 2007年11月22 |
A New Anthraquinone Glycoside Biotransformed by Beauveria bassiana |
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| YIN Zhi-Qi,WANG Lei,YE Wen-Cai,ZHANG Jian,ZHOU Chang-Lin,ZHAO Shou-Xun.A New Anthraquinone Glycoside Biotransformed by Beauveria bassiana[J].Chinese JOurnal of Natural Medicines,2008,6(2):103-104. | |
| Authors: | YIN Zhi-Qi WANG Lei YE Wen-Cai ZHANG Jian ZHOU Chang-Lin ZHAO Shou-Xun |
| Institution: | YIN Zhi-Qi, WANG Lei, YE Wen-Cai, ZHANG Jian, ZHOU Chang-Lin, ZHAO Shou-Xun(Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanfing 210009; 2 Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanfing 210028; 3.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632; 4 School of Life Science ＆ Technology, China Pharmacectical University, Nanfing 210009, P. R. China) |
| Abstract: | AIM: To study the rhein methylglucosidation biotransformed by Beauveria bassiana. METHODS: Rhein was biotransformed by Beauveria bassiana through growing culture. The fermentation broth wag centrifuged and extracted with EtOAc, and then EtOAc extract was subjected to a series of chromatographic separation methods to afford a new compound. The structure of the new compound was elucidated by means of 1H and 1,'3C NMR spectroscopic analysis, including 2D NMR technique. RESULTS: The product Was identified as a glycosylated derivative of rhein, and the structure was elucidated to be 7-O-(4'-methoxy-β-D-glucopyranoside) aloe-emodin (1). CONCLUSION: The compound isolated is a new one. |
| Keywords: | Beauveria bassiana Rhein Glycosylation |
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