磁共振氢质子波谱在颅脑疾病诊断中的应用

目的：评价磁共振氢质子渡谱（^1H—MRS）在颅脑疾病诊断中的应用价值。方法：采用GE1．5TMR扫描仪，应用单体素激励回波探测法，对45例正常对照及115例病变者进行^1H—MRS波形、代谢物测定，并对检测结果予以统计分析。结果：颅脑疾病氮-乙酰门冬氨酸（NAA）、胆碱（Cho）、肌酐（Cr）和乳酸（Lac）、脂质（Lip）以及NAA/Cho、Cho／Cr相对正常对照组有统计学差异（P≤0．05）。结论：^1H—MRS在颅脑疾病诊断病变中差异均有统计学意义．将波谱与常规图像结合联合应用可提高诊断正确率。

Hydrogen Proton Magnetic Resonance Spectroscopy of Brain Diseases

Objective To evaluate the hydrogen proton magnetic resonance spectroscopy（^1H-MRS） in the diagnosis of brain diseases. Methods 1.5 Tesla MR scanner of GE Company was used, and single voxel technique was applied in 45 healthy subjects as control group and 115 patients presented with different brain lesions. The ^1H-MRS metabolites waveform were evaluated, and the results were analyzed. Results The values of NAA, Cho, Cr and Lac, Lip and NAA/Cho as well as Cho/ Cr from the patients showed a statistical difference to the control group, with P not more than 0.05. Conclusion The ^1H- MRS results of lesions in the brain disease show statistical differences, and when combined with conventional MRI can contribute to a confident diagnosis.