216例药物性肝炎的临床分析

目的：提高对药物性肝炎的认识。方法：对216例药物性肝炎的发病规律及临床特征进行分析。结果：药物性肝炎多发生于长期、联合使用有肝毒性的药物而又无肝功监测的患者，多见于农民及工人。多发生于服药后十天至一个月。有HBsAg阳性者更易发生药物性肝炎及重症肝炎，且病死亡率高。结论：影响药物性肝炎的因素有患者的文化程度、药物的种类、用药时间、联合用药、HBsAg阳性、肝功能的监测等。

Analysis of clinical feature of 216 patients of drug hepatitis.

Objective:To increase the understanding of drug hepatitis.Methods:Analysis of the clinical feature and etiology of 216 patients with drug hepatitis.Results:Most of the drug hepatitis happen in the patients with long-termly,combined use hepatotoxic drugs without liver function monitor,and most of the patients are peasants and workers.Drug hepatitis offen appears duing the 10th day to one month of treatment.Patients with HBsAg positive are at higher risk for drug hepatitis,enen severe hepatitis,and the mortality is higher.Conclusion:The factors that influence drug hepatitis include patient'seducational degree,what kind of drug used,how long drugs used,combined drugs use,HBsAg positive,liver function monitor,etc.