肝细胞癌的表观遗传学研究进展

肝细胞癌简称肝癌(hepatocellular carcinoma)的发病率、病死率呈逐年上升趋势,尽管几种主要危险致病因素已经比较明确,但是肝癌发生的确切的分子生物学机制尚不完全清楚.近年来越来越多的证据表明,表观遗传修饰(epigenetics)在肝癌的发生发展中具有非常重要的作用.本文将就DNA的异常甲基化、组蛋白异常修饰与肝癌的关系,肝癌的表观遗传学检测及表观遗传学治疗现状做一综述.

Progress on epigenetic research of hepatocellular carcinoma

The incidence and mortality of hepatocellular carcinoma have increased in recent decades. Although the major etiological factors have been identified, the exact molecular biology mechanism remains unclear. Re- cently, more and more evidences prove that epigenetics mechanism plays an important role in hepatoceUular carcino-ma. Here we try to make a progress on the abnormal epigenetics changes, epigenetics detection and treatments of hepatocellualr carcinoma.