还原型谷胱甘肽对急性有机磷农药中毒肝功能损害的治疗

目的探讨还原型谷胱甘肽对急性有机磷农药中毒肝功能损害的治疗价值。方法将58例急性有机磷农药中毒伴肝功能损害的患者随机分为Ⅰ组和Ⅱ组。Ⅰ组加用还原型谷胱甘肽1.2g/d.qd.ivgtt,其余治疗两组相同。于治疗前后测定血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、凝血酶原时间(PT)等,并观察临床病情。结果Ⅰ组AST、ALT、PT较Ⅱ组明显好转(P<0.01);Ⅰ组AST、ALT好转率较Ⅱ组高(P<0.05)。结论还原型谷甘肽对急性有机磷农药中毒肝功能损害具有较好的治疗作用。

Treatment Effect of Reduced Glutathione on Liver Function Damage in Patient with Acute Organophosphorus Pesticide Poisoning

Objective To study the effect of reduced glutathione(GSH) on liver function damage as treatment in patient with acute organophosphorus pesticide poisoning.Methods A total of 58 patients with acute organo-phosphorus pesticide poisoning were randomly divided into two groups.28 patients were given GSH in a dose of 1.2g/d through intravenous drip for 7 days as GSH group,and 30 patients were not given GSH to serve as control group.The same treatment was given to both groups other than GSH.The liver function related items were determined.Results After the treatment,plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST),prothrom-bin time(PT) significantly decreased in both treatment groups,but the decrease of all these indexes was more marked in GSH group(P<0.01).Conclusion GSH has beneficial effects in protecting liver function in patients with acute organophosphorus pesticide poisoning combined with liver damage.