| EXPERIMENTAL STUDY ON DIMETHYLSULFOXIDEINDUCED DIFFERENTIATION OF HUMAN ESOPHAGEALEPITHELIAL CARCINOMA CELLS |
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| 引用本文： | 谭立军,李慧,易静,汤雪明,沈忠英. EXPERIMENTAL STUDY ON DIMETHYLSULFOXIDEINDUCED DIFFERENTIATION OF HUMAN ESOPHAGEALEPITHELIAL CARCINOMA CELLS[J]. 上海第二医科大学学报, 1998, 0(Z1) |
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| 作者姓名： | 谭立军 李慧 易静 汤雪明 沈忠英 |
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| 作者单位： | Tan Lijun ; Li Hui ; Yi Jing ; Tang Xueming (Cell Biology Laboratory，Department of Biophyscis，SSMU，Shanghai 200025)Shen Zhongying (Department of Pathology，Shantou University Medical College，Shantou 515031) |
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| 摘 要： | ResumeObjeCtif11adidddmontrdqueietraitementdestumeurssolidespari'inductiondeladill6renciationn'etaitpasaussiefficacequeceluideleucdmieaiguepromydlocytaire(LAP)parl'acideretinoiquetouttrans,Antifestdonen4cessaired'eoplorerd'autresinducteurspourlathdrapiedestumeurssolide.dimethylsulloxyde(DMSO)estactuellementconsiderscommecandidat.WthodesEnutilisantDMSOcommeinducteurdansuneligndecancdreusedpithelialed'OesOPhagehamaineetcomparantavecARtt,nonsavonsetudidlamoPPhologtecellulaire,iecyclecellu…
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EXPERIMENTAL STUDY ON DIMETHYLSULFOXIDE INDUCED DIFFERENTIATION OF HUMAN ESOPHAGEAL EPITHELIAL CARCINOMA CELLS |
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| Tan Lijun , Li Hui , Yi Jing , Tang Xueming. EXPERIMENTAL STUDY ON DIMETHYLSULFOXIDE INDUCED DIFFERENTIATION OF HUMAN ESOPHAGEAL EPITHELIAL CARCINOMA CELLS[J]. Journal of Shanghai Second Medical University(Foreign Language Edition), 1998, 0(Z1) |
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| Authors: | Tan Lijun Li Hui Yi Jing Tang Xueming |
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| Abstract: | Objective The treatment of solid tumors by means of differentiation induction has not yet beengained such broken - through success as all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL).To explore more effective inducers for solid tumor therapy, dimethyl sulfoxide (DMSO) is considered as acandidate. Methods In the present study, DMSO was used as inducer to human esophageal cancer cell lines invitro, in compared with classical inducer ATRA, in terms of morphology, cell cycle, growth inhibition, cytokeratin4 expression, gap junction-mediated dye transfer and tumorigenecity in nude mice. Results DMSO as well asATRA induced differentiation of human esophageal carcinoma cells. However, DMSO was confirmed to be moreeffective for induced differentiation of esophageal carcinoma cells than ATRA. Conclusion The results suggestedthat DMSO might have a good prospect in the treatment of solid tumors. |
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| Keywords: | induced differentiation esophageal cancer tumor therapy dimethylsulfoxide all-trans retinoic acid |
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