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压电石英晶体生物传感器的血浆凝血因子检测系统的效能研究
引用本文:屈玲,邓勇,府伟灵.压电石英晶体生物传感器的血浆凝血因子检测系统的效能研究[J].第三军医大学学报,2004,26(18):1661-1663.
作者姓名:屈玲  邓勇  府伟灵
作者单位:第三军医大学西南医院检验科,重庆,400038;上海交通大学自动化系,上海,200030
基金项目:国家高技术研究发展计划(863计划),国家科技攻关项目,国家自然科学基金
摘    要:目的研究用压电石英晶体传感器进行凝血因子检测的系统,介绍血浆凝血因子检测系统的工作原理.方法利用压电石英晶体的逆压电反应,基于模糊和解耦控制技术,采用单片机进行恒温恒湿控制和频率计数,测得血浆凝集时间,来确定凝血因子的活性和含量.结果本检测系统提高了凝血因子检测的方便性、精度和一致性.结论压电石英晶体传感器用于凝血因子检测具有精度高和成本低等优点,有广阔的临床应用和推广前景.

关 键 词:压电石英晶体  生物传感器  凝血因子  检测  系统
文章编号:1000-5404(2004)18-1661-03
修稿时间:2004年5月6日

A system for detection of blood coagulation factors using piezoelectric quartz crystal biosensor
QU ling ,DENG Yong ,FU Wei ling.A system for detection of blood coagulation factors using piezoelectric quartz crystal biosensor[J].Acta Academiae Medicinae Militaris Tertiae,2004,26(18):1661-1663.
Authors:QU ling  DENG Yong  FU Wei ling
Institution:QU ling 1,DENG Yong 2,FU Wei ling 1
Abstract:Objective To design a system for the detection of coagulation factors using piezoelectric quartz crystal (PQC) sensors and to introduce its operating principle and the main components. Methods The contrary piezoelectric response of quartz crystal was used. Based on the fuzzy and decoupling control, a singlechip computer was used for constant temperature and constant humidity control and frequency count. The plasma coagulation time was measured for the purpose of determination of the activities and contents of the coagulation factors. Results The system was convenient, precise, and consistent for the detection of the coagulation factors. Conclusion PQC sensors with high accuracy and low cost can be used in the detection of coagulation factors and has a bright future in clinical practice.
Keywords:piezoelectric quartz crystal  biosensor  coagulation factor  detection  system
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