| 头序楤木叶中三萜化学成分的研究 |
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| 引用本文： | 易杨华,顾竟勤,肖凯,王忠壮,林厚文.头序楤木叶中三萜化学成分的研究[J].药学学报,1997,32(10):769-772. |
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| 作者姓名： | 易杨华 顾竟勤 肖凯 王忠壮 林厚文 |
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| 作者单位： | 第二军医大学药学院天然药物化学教研室,上海200433 |
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| 摘 要： | 从头序楤木(Aralia dasyphyla Miq)叶中分离到6个三萜化合物,用化学方法和波谱(UV,IR,MS,1HNMR,13CNMR,13CDEPT,HMQC,HMBC)分析,确定其中4种化合物的结构,分别为齐墩果酸(I),16β-羟基-18β-H-齐墩果酸(I),齐墩果酸-28-O-β-D-吡喃葡萄糖甙(II)和16β-羟基-18β-H-齐墩果酸-28-O-β-D-吡喃葡萄糖甙(IV)。用NOESY谱确定化合物I的立体构型。以上4个化合物均为首次从该植物中分离到,化合物IV为新化合物。
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| 关 键 词： | 头序楤木 三萜 皂甙 |
| 收稿时间： | 1996-08-13 |
STUDIES ON TRITERPENOIDS AND THEIR GLYCOSIDES FROM ARALIA DASYPHYLLA MIQ |
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| Y H Yi,J Q Gu,K Xiao,Z Z Wang,H W Lin.STUDIES ON TRITERPENOIDS AND THEIR GLYCOSIDES FROM ARALIA DASYPHYLLA MIQ[J].Acta Pharmaceutica Sinica,1997,32(10):769-772. |
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| Authors: | Y H Yi J Q Gu K Xiao Z Z Wang H W Lin |
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| Institution: | Department of Medical Chemistry of Natural Products, School of Pharmacy, Second Military Medical University, Shanghai 200433. |
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| Abstract: | The structures of two triterpenoids and their glycosides were isolated from Aralia dasyphylla Miq. Their structures have been identified to be oleanoic acid(I), 16 beta-hydroxy-18 beta-H-oleanoic acid(II), oleanoic acid-28-O-beta-D-glucopyranoside(III) and 16 beta-hydroxy-18 beta-H-oleanoic acid-28-O-beta-D-glucopyranoside(IV), respectively, mainly through interpretation of UV, IR, MS, 1H and 13CNMR, DEPT, HMQC and HMBC spectra data. The stereochemistry of II has been confirmed by NOESY. Pharmacological experiments showed that the total saponins exerted preventative effect on CCl4-induced liver injury of male mice and hypoglycemic effect on a model of alloxan-induced diabetes in rats. |
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| Keywords: | Triterpenoids Saponia Aralia dasyphylla Miq |
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