| 脑膜瘤组织中MMP-9、P53的表达 |
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| 引用本文： | 马春晓,徐国本. 脑膜瘤组织中MMP-9、P53的表达[J]. 郑州大学学报(医学版), 2004, 39(4): 616-619 |
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| 作者姓名： | 马春晓 徐国本 |
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| 作者单位： | 郑州大学第一附属医院神经外科,郑州,450052;平顶山市第一人民医院神经外科,平顶山,467000;郑州大学第一附属医院神经外科,郑州,450052 |
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| 摘 要： | 目的 :探讨脑膜瘤组织中基质金属蛋白酶 9(MMP 9)和P5 3蛋白的表达及与肿瘤血管形成和临床病理之间的关系。方法 :应用免疫组织化学法检测 5 2例脑膜瘤组织中MMP 9、P5 3蛋白的表达情况及微血管密度(MVD) ,并结合临床病理参数进行综合分析。结果 :MMP 9、P5 3的表达与脑膜瘤组织病理分级、MVD、侵袭行为、瘤周水肿显著相关 (P <0 .0 5 )。结论 :MMP 9、P5 3在肿瘤血管形成、恶性进展和浸润、瘤周水肿等方面起着重要作用。检测脑膜瘤组织中MMP 9、P5 3的表达对进一步了解脑膜瘤生物学行为、临床表现和判断预后具有重要价值
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| 关 键 词： | MMP-9 P53 脑膜瘤 血管生成 临床病理学 免疫组织化学 |
| 修稿时间： | 2003-10-16 |
Expression of MMP-9 and P53 in meningiomas tissues |
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| MA Chunxiao ,),XU Guoben ) ). Expression of MMP-9 and P53 in meningiomas tissues[J]. Journal of Zhengzhou University: Med Sci, 2004, 39(4): 616-619 |
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| Authors: | MA Chunxiao ) XU Guoben ) ) |
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| Affiliation: | MA Chunxiao 1,2),XU Guoben 1) 1)Department of Neurosurgery,the First Affiliated Hospital,Zhengzhou Universiy,Zhengzhou 450052 2)Deportment of Neurosurgery,the First People's Hospital of Pingdingshan,Pingdingshan 467000 |
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| Abstract: | Aim: To investigate the relationship between the expression of MMP 9 and P53 in meningiomas and tumor angiogenesis and pathological characteristic. Methods: Expression of MMP 9 ,P53, and factor VIII related antigen in 52 cases of meningiomas were detected by immunohistochemistry. The pathological parameters were also analyzed. Results: In meningiomas, the expression of MMP 9 and P53 were closely related to the pathological grade, microvessel density (MVD), aggressive behavior, and peritumoral edema ( P <0.05). Conclusions: In meningiomas,MMP 9 and P53 may play an important role in angiogenesis, malignancy progress, brain invasion, and peritumoral edema. Detection of expression of MMP 9 and P53 may be of value in further understanding the biological behavior, clinical performance, and predicting the prognosis of meningiomas. |
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| Keywords: | MMP 9 P53 meningiomas angiogenesis clinical pathology immunohistochemistry |
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