| 硷式醋酸铅对化学致癌物诱发小鼠肺肿瘤的影响 |
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| 引用本文： | 陈增良,徐英含. 硷式醋酸铅对化学致癌物诱发小鼠肺肿瘤的影响[J]. 浙江大学学报(医学版), 1993, 0(4) |
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| 作者姓名： | 陈增良 徐英含 |
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| 作者单位： | 浙江医科大学病理解剖学教研室，浙江医科大学病理解剖学教研室 |
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| 摘 要： | 本文研究了硷式醋酸铅(BLA)对化学致癌物诱发小鼠肺肿瘤的影响。实验结果表明:①单纯BLA处理不能诱发小鼠肿瘤;②BLA对多种化学致癌物诱发小鼠肺肿瘤作用有不同效应。BLA明显促进二甲基亚硝胺(DMN)诱发小鼠肺肿瘤的发生率,增加每鼠平均肺肿瘤数;相反,氨基甲酸乙酯(EC)诱发小鼠肺肿瘤的作用则受抑制,使EC BLA组小鼠肺肿瘤的平均瘤结数明显减少;BLA对甲基硝基亚硝基胍(MNNG)诱发小鼠肺肿瘤作用无明显影响。
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| 关 键 词： | 铅/类似物和衍生物 致癌物/拮抗剂和抑制剂 二甲基亚硝胺 氨基甲酸乙酯 甲基硝基亚硝基胍 肺肿瘤/化学诱导 小鼠 |
EFFECT OF BASIC LEAD ACETATE ON INDUCTION OF LUNG TUMORS IN MICE TREATED WITH CHEMICAL CARCINOGENS |
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| Chen Zengliang,Xu Yinghen. EFFECT OF BASIC LEAD ACETATE ON INDUCTION OF LUNG TUMORS IN MICE TREATED WITH CHEMICAL CARCINOGENS[J]. Journal of Zhejiang University. Medical sciences, 1993, 0(4) |
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| Authors: | Chen Zengliang Xu Yinghen |
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| Affiliation: | Chen Zengliang;Xu Yinghen Department of Pathology |
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| Abstract: | The effects of basic lead acetate (BLA) on the induction of lung tumors were studied in mice treated with chemical carcinogens. It was demonstrated that BLA enhanced the deve- lopment of lung tumors in mice treated with dimethylnitrosamine to thus raise the incidence in lung tumor-bearing mice and increase the average number of lung tumors in each mouse. On the contrary, the effect of BLA on chemical tumorigenesis was found in mice treated with urethan to decrease the average number of lung tumors in each mouse. But no significant dif- ference was observed between the mice treated with N-methyl-N-nitro-nitroso-guanidine (MNNG) and those with MNNG plus BLA. No tumor was found in mice treated with BLA alone under our experimental conditions. |
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| Keywords: | Lead/analogs Carcinogens/antag Dimethylnitrosamine Methylnitronitrosoguanidine Urethan Lung tumor/chem ind Mice |
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