| 溃疡性结肠炎相关性结直肠癌中AOM/DSS模型应用研究 |
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| 引用本文： | 吴琼,郭蒙,叶华,朱宇珍,郑学宝.溃疡性结肠炎相关性结直肠癌中AOM/DSS模型应用研究[J].海南医学,2013,24(19):2880-2883. |
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| 作者姓名： | 吴琼 郭蒙 叶华 朱宇珍 郑学宝 |
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| 作者单位： | [1]广东医学院药理教研室,广东湛江524023;广东医学院广东天然药物研究与开发重点实验室广东湛江524023 [2]广东医学院广东天然药物研究与开发重点实验室,广东湛江524023 |
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| 基金项目： | 国家自然科学基金（编号：30772701）;广东省科技计划项目（编号：2011B03170065）;广东省建设中医药强省项目（编号：20112144）;湛江市科技攻关项目（编号：2009C3104003） |
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| 摘 要： | 在化学诱导结肠炎相关性结肠癌模型中,氧化偶氮甲烷（Azoxymethane,AOM）/葡聚糖硫酸钠（Dextran sodium sulfate,DSS）可以大大缩短结肠炎诱导癌变的时间,重现人类结直肠癌隐窝病灶-腺瘤-腺癌发展顺序.由于AOM/DSS模型重现率高,以及简单的造模方法,已成为化学预防研究的典型造模方法.本文从AOM/DSS动物模型、炎症相关性癌症及结直肠癌中AOM/DSS模型的应用、结直肠癌组织学三个方面对炎症相关性结直肠癌作一综述.
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| 关 键 词： | 溃疡性结肠炎相关性结直肠癌 结直肠癌 动物模型 AOM DSS |
Advances on the application of AOM/DSS model in ulcerative colitis associated colorectal cancer |
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| WU Qiong,GUO Meng,YE Hua,ZHU Yu-zhen,ZHENG Xue-bao.Advances on the application of AOM/DSS model in ulcerative colitis associated colorectal cancer[J].Hainan Medical Journal,2013,24(19):2880-2883. |
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| Authors: | WU Qiong GUO Meng YE Hua ZHU Yu-zhen ZHENG Xue-bao |
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| Institution: | 1. Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, CHINA; 2. Guangdong Key Laboratory for Research and Development of Natural Drugs, Zhanjiang 524023, Guangdong, CHINA |
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| Abstract: | Among the chemically induced CRC models, the combination of a single hit of azoxymethane （AOM） to the inflammatory agent dextran sodium sulpate （DSS） in rodents has proven to dramatically shorten the la- tency time for induction of CRC and to rapidly recapitulate the aberrant crypt ofci-adenoma-careinoma sequence that occurs in human CRC. Because of its high reproducibility and potency, as well as the simple and affordable mode of application, the AOM/DSS has become an outstanding model for studying colon carcinogenesis and apowerful plat- form for chemopeventice intervention studies. This review briefly summarizes the current advances in the AOM/DSS model, inflammation and tumorigenesis in the AOM/DSS, as well as histogenesis of CRC in the AOM/DSS model. |
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| Keywords: | Ulcerative colitis associated colorectal cancer Colorectal cancer Animal model AOM/DSS |
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