| 盐酸替罗非班对急性冠脉综合征患者血清高敏C-反应蛋白水平的影响 |
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| 引用本文： | 陈芳,马红梅,唐世琪.盐酸替罗非班对急性冠脉综合征患者血清高敏C-反应蛋白水平的影响[J].中国临床保健杂志,2009,12(1):25-27. |
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| 作者姓名： | 陈芳 马红梅 唐世琪 |
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| 作者单位： | 武汉大学人民医院心血管内科,武汉,430060 |
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| 摘 要： | 目的观察盐酸替罗非班对急性冠脉综合征(ACS)患者血清高敏C-反应蛋白(HS-CRP)水平的影响,了解盐酸替罗非班对ACS可能的炎症抑制机制。方法55例初诊为ACS的患者随机分为对照组(n=31)和试验组(n=24),试验组在对照组给予口服阿司匹林、氯吡格雷等常规治疗药物的基础上加用静脉滴注盐酸替罗非班,用超敏乳胶增强免疫比浊法测定ACS患者治疗前后hs-CRP水平。结果两组治疗前hs-CRP水平比较无明显差异(P>0.05);两组治疗后hs-CRP水平明显下降(P<0.01);治疗后两组hs-CRP水平比较差异有统计学意义(P<0.01)。结论盐酸替罗非班作为一种高效、高选择性的血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂,能够通过抑制炎性反应从而延缓ACS进程。
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| 关 键 词： | 冠状动脉疾病 C反应蛋白质 血小板聚集抑制剂 |
The effect of tirofiban hydrochloride on serum hs-CRP level in acute coronary syndromes |
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| CHEN Fang,MA Hong-mei,TANG Shi-qi.The effect of tirofiban hydrochloride on serum hs-CRP level in acute coronary syndromes[J].Chinese JOurnal of Clinical Healthcare,2009,12(1):25-27. |
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| Authors: | CHEN Fang MA Hong-mei TANG Shi-qi |
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| Institution: | Department of Cadiology;Renmin Hospital of Wuhan University;Wuhan 430060;China |
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| Abstract: | Objective To observe the effect of tirofiban hydrochlotide on serum hs-CRP level,and to approach the mechanism of inhibiting inflammation of it in acute coronary syndromes.Method 55 patients were randomly divided into two groups:control group(n=31) and tirofiban group(n=24),they all were treated with tirofiban hydrochloride plus routine medicine,Serum hs-CRP levels were determinded by the latex enhanced immunoturbidimetric method.Results The level of hs-CRP had no significant difference between two groups b... |
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| Keywords: | Coronary disease C-reactive protein Platelet aggregation inhibitors |
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