Neuroprotective Properties of Nootropic Dipeptide GVS-111 in in Vitro Oxygen-Glucose Deprivation, Glutamate Toxicity and Oxidative Stress |
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| Authors: | N. A. Andreeva E. V. Stel'mashuk N. K. Isaev R. U. Ostrovskaya T. A. Gudasheva I. V. Viktorov |
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| Affiliation: | (1) Brain Research Institute, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate. |
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| Keywords: | cerebellar granule cells ischemia GVS-111 piracetam glutamate |
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