| 联苯双酯固体脂质纳米粒注射给药在大鼠体内的药动学 |
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| 引用本文： | 张洪,毕卓悦,詹新安,成蓓. 联苯双酯固体脂质纳米粒注射给药在大鼠体内的药动学[J]. 中国医院药学杂志, 2010, 0(2) |
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| 作者姓名： | 张洪 毕卓悦 詹新安 成蓓 |
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| 作者单位： | 武汉大学人民医院药学部;武汉大学药学院; |
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| 摘 要： | 目的:研究联苯双酯固体脂质纳米粒在大鼠体内的药动学。方法:制备联苯双酯固体脂质纳米粒,大鼠尾静脉注射给药,高效液相色谱法测定不同时间血浆中联苯双酯的浓度,通过3P97程序计算药动学参数。结果:药动学研究表明联苯双酯固体脂质纳米粒消除较慢,生物利用度较高,无论是药物溶液还是纳米混悬液,在大鼠体内的药动学过程均符合二室模型。结论:与药物溶液相比,联苯双酯固体脂质纳米粒具有明显的缓释效果,同时还能提高药物的生物利用度。
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| 关 键 词： | 联苯双酯 固体脂质纳米粒 药动学 |
Pharmacokinetics of bifendate solid lipid nano-particles rats |
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| ZHANG Hong,BI Zuo-yue,ZHAG Xin-an ,CHENG Bei. Pharmacokinetics of bifendate solid lipid nano-particles rats[J]. Chinese Journal of Hospital Pharmacy, 2010, 0(2) |
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| Authors: | ZHANG Hong BI Zuo-yue ZHAG Xin-an CHENG Bei |
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| Affiliation: | ZHANG Hong1,BI Zuo-yue2,ZHAG Xin-an 2,CHENG Bei 2(1.Department of Pharmacy,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China,2.Department of Pharmacy,Wuhan University,Hubei Wuhan 430072,China) |
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| Abstract: | OBJECTIVE To study the pharmacokinetics of bifendate solid lipid nanoparticles in rats.METHODS The DDB-SLN was prepared.The concentrations of DDB in plasma of rats and their pharmacokinetic behaviors after iv administration were studied by HPLC.The pharmacokinetic parameters were computed by software program 3P97.RESULTS The results of pharmacokinetics showed the clearance of bifendate solid lipid nano-particles was slowly,both of DDB solution and DDB-SLN in vivo were accord with two-compartment model.CONCL... |
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| Keywords: | bifendate solid lipid nano-particles pharmacokinetics |
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