|
|||||
|
|
| 姜黄素白蛋白纳米混悬剂的制备和体外释药研究 | |
| 引用本文： | 张华,张良珂,袁佩,汪程远. 姜黄素白蛋白纳米混悬剂的制备和体外释药研究[J]. 中国中药杂志, 2011, 36(2): 132-135 |
| 作者姓名： | 张华 张良珂 袁佩 汪程远 |
| 作者单位： | 1. 重庆医科大学,药学院,重庆市生物化学与分子药理学重点实验室,重庆,400016;重庆医科大学,生命科学院,重庆,400016 2. 重庆医科大学生命科学院,重庆,400016 3. 重庆工商大学,药物化学与化学生物学研究中心,重庆,400067 |
| 摘 要： | 目的:制备姜黄素白蛋白纳米混悬剂,并考察其体外释药性能.方法:采用溶剂蒸发技术制备姜黄素白蛋白纳米混悬剂,并对其形态、粒径分布和体外释药性质进行了研究.结果:姜黄素白蛋白纳米混悬剂平均粒径为245.2 nm,姜黄素白蛋白纳米混悬剂冻干粉复溶后平均粒径为240.3 nm.姜黄素白蛋白纳米混悬剂形态圆整,粒径分布均匀,平均包封率为(42.39±0.91)%,72 h体外累计释药率为96%.结论:姜黄素白蛋白纳米混悬剂制备方法简便,有望成为姜黄素的新型纳米给药系统. |
| 关 键 词： | 姜黄素 白蛋白 纳米混悬剂 |
| 收稿时间： | 2010-08-03 |
Preparation and in vitro release characteristics of curcumin in nanosuspensions |
|
| ZHANG Hu,ZHANG Liangke,YUAN Pei and WANG Chengyuan. Preparation and in vitro release characteristics of curcumin in nanosuspensions[J]. China Journal of Chinese Materia Medica, 2011, 36(2): 132-135 | |
| Authors: | ZHANG Hu ZHANG Liangke YUAN Pei WANG Chengyuan |
| Affiliation: | Chongqing Key Laboratory of Biochemistry &Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China;Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China; 3. Research Center of Medical Chemistry & Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China;Chongqing Key Laboratory of Biochemistry &Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China;Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China; 3. Research Center of Medical Chemistry & Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China;Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China; 3. Research Center of Medical Chemistry & Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China;Research Center of Medical Chemistry & Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China |
| Abstract: | Objective : To prepare curcumin albumin nanosuspensions and study its release characteristics in vitro. Method : Curcumin albumin nanosuspensions were prepared by solvent evaporation method. The nanosuspensions were characterized in terms of morphology, size, encapsulation efficiency and in vitro drug release. Result : The mean size of albumin nanosuspensions before lyophilization was 245.2 nm and 240.3 nm after reconstitution. The distribution of particle size was uniform. The encapsulation efficiency was(42.39±0.91)%. In vitro release study revealed that the 72 h accumulative release percentage reached 96%. Conclusion : The method described to prepare curcumin albumin nanosuspensions is simple. It might be a novel vehicle potentially for nanoparticle drug delivery system of curcumin. |
| Keywords: | curcumin albumin nanosuspensions |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |