急性脑梗死患者血浆纤维蛋白原和D-二聚体水平的变化

目的 探讨急性脑梗死患者血浆纤维蛋白原与D-二聚体水平的变化及其临床意义.方法分别应用Clauss法及乳胶免疫比浊法检测96例急性脑梗死患者及30例健康对照者血浆纤维蛋白原和D-二聚体水平.结果急性脑梗死组血浆纤维蛋白原和D-二聚体水平明显高于对照组(P<0.05),且随着急性脑梗死严重程度的增加,血浆纤维蛋白原和D-二聚体水平逐渐增高(P<0.05).急性脑梗死患者血浆纤维蛋白原水平与D-二聚体水平呈显著正相关(r=0.423,P<0.05).结论 脑梗死患者血浆纤维蛋白原和D-二聚体水平变化对判断脑梗死的发生及病情轻重具有重要的意义.

Changes of Plasma Fibrinogen and D-Dimer in Patients with Acute Cerebral Infarction

Aim To discuss the changes and significance of plasma fibrinogen and D-dimer in patients with acute cerebral. Methods The levels of plasma fibrinogen and D-dimer in 96 cases of acute cerebral infarction and 30 healthy controls were detected with Clauss method and immunoturbidimetry method, respectively. Results The levels of plasma fibrinogen and D-dimer were significantly higher than those in the control group (P<0.05). Moreover, with the aggression of acute cerebral infarction, the levels of fibrinogen and D-dimer were increasing, gradually (P<0.05).The levels of fibrinogen were positively correlated with the levels of D-dimer (r=0.423, P<0.05). Conclusion The levels of plasma fibrinogen and D-dimer are useful for the diagnosis and evaluation of disease severity.